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For medications like liraglutide, this ensures that the clinical effects, including weight reduction and gastrointestinal side effects, should be essentially identical, says Michael Genovese, MD, chief medical adviser at AscendantNY in New York City

Some patients report that their usual morning coffee becomes less tolerable during the first few weeks of semaglutide treatment, particularly following dose escalations

heterogeneity in the included studies

Organizations need to understand not just what they spent on GLP-1s last quarter, but which members are driving utilization, whether formulary controls are working, and where costs are heading next

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